Randalbork

BIO
As a person continues to struggle with Opiate Addiction, the brain adapts to the overwhelming surges in dopamine by producing less dopamine or by reducing the number of dopamine receptors in the reward circuit. The result of Heroin Addiction is a lessening of dopamine’s impact on the reward circuit, which reduces the abuser’s ability to enjoy the drugs, as well as the things in life that previously brought pleasure. This decrease compels the addicted person to keep abusing drugs in an attempt to bring the dopamine function back to normal, except now larger amounts of the drug are required to achieve the same dopamine high - an effect known as tolerance. Long-term Oxycontin Addiction causes significant changes in other brain chemical systems and circuits as well.